Hydroxyamine hydrochloride → HCID 178518587, compound

HRID 128030Notes

Reaction equation

HRID 128030 reaction equation
C([C:9]1[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=1[NH:16][C:17]([NH:19][CH:20](C)C)=[O:18])(=O)C1C=CC=CC=1.Cl.N[OH:25]>C(O)C>[NH:16]1[C:10]2[C:9](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:20]=[N+:19]([O-:25])[C:17]1=[O:18]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 12750795N-(2-Benzoyl-4-chlorophenyl)-N′-(1-methylethyl)urea

Product 1

HCID 178518587HCID 178518587, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred mixture of 6.34 g (0.02 mole) of 1-(2-benzoyl-4-chlorophenyl)-3-isopropylurea and 4.17 g (0.06 mole) of hydroxylamine hydrochloride in 100 ml of ethanol was refluxed for 48 hr, and then cooled. The suspended crystals were collected on a filter, washed with alcohol, and then dried in air to give 4.60 g (84%) of 6-chloro-4-phenyl-(2(1H)-quinazolinone 3-oxide as yellow crystals, mp 267°-269° (dec.).

Workup

  1. temperaturewas refluxed for 48 hr
  2. temperaturecooled
  3. customThe suspended crystals were collected on a filter
  4. washwashed with alcohol
  5. customdried in air

Sources & evidence

ORD record
ord-12ec66151e09476ca7ce8e5d5b238fc4
Source dataset
uspto-grants-1981_03
Patent number
US04258187

Reaction notes

Loading…