Acetic Acid → HCID 18425022, compound

HRID 1280322Notes

Reaction equation

HRID 1280322 reaction equation
[Cl:1][C:2]1[C:3]([CH2:12][C:13]2[CH:18]=[C:17]([N+:19]([O-])=O)[CH:16]=[C:15]([Cl:22])[C:14]=2[Cl:23])=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:10])[F:9].C(O)(=O)C.C(O)C>[Fe].C(OCC)(=O)C>[Cl:1][C:2]1[C:3]([CH2:12][C:13]2[CH:18]=[C:17]([NH2:19])[CH:16]=[C:15]([Cl:22])[C:14]=2[Cl:23])=[N:4][N:5]([CH3:11])[C:6]=1[O:7][CH:8]([F:9])[F:10]

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 702EthanolHCID 15390560HCID 15390560, compound

Product 1

HCID 18425022HCID 18425022, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 8857Ethyl AcetateSolvent

Procedure

At 70—75° C., 2.2 g (5.7 mmol) of 4-chloro-3-(2,3-dichloro-5-nitrobenzyl)-5-difluoromethoxy-1-methyl-1H-pyrazole were added to a mixture of 1.7 g (30 mmol) of iron, 5 ml of acetic acid and 10 ml of ethanol. The mixture was then heated under reflux for 1 hour. The reaction mixture was then admixed with 50 ml of ethyl acetate and filtered through a bed of diatomaceous earth. Finally, the mixture was concentrated. Yield: 2 g;

Workup

  1. temperatureThe mixture was then heated
  2. temperatureunder reflux for 1 hour
  3. filtrationfiltered through a bed of diatomaceous earth
  4. concentrationFinally, the mixture was concentrated

Sources & evidence

ORD record
ord-df06aca4b1444e8d8cf961812013a954
Source dataset
uspto-grants-2002_09
Patent number
US06451734B1

Reaction notes

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