反应详情

To 3-(2-chlorophenyl)-7-methylthio-1-phenyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (2 g) in 20 mL of tetrahydrofuran at 0° C. was added a solution of 8.1 g of Oxone® in 24 mL of water. The mixture was stirred for 5 hours at room temperature, diluted with ethyl acetate, washed with brine, dried over sodium sulfate, filtered, and evaporated to give 2 g of 3-(2-chlorophenyl)-7-methanesulfonyl-1-phenyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, m.p. 185.8-186.3° C.

1. washwashed with brine
2. dry with materialdried over sodium sulfate
3. filtrationfiltered
4. customevaporated