Oxalyl chloride → HCID 54045789, compound

HRID 1280760Notes

Reaction equation

HRID 1280760 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[CH:8][C:9]([OH:11])=O)[CH:2]=1.C(Cl)(=O)C(Cl)=O.[CH:18]1[C:28]2[CH2:27][CH2:26][C:25]3[CH:29]=[CH:30][CH:31]=[CH:32][C:24]=3[CH:23]([N:33]3[CH2:38][CH2:37][CH:36]([CH2:39][CH2:40][CH2:41][CH2:42][NH2:43])[CH2:35][CH2:34]3)[C:22]=2[CH:21]=[CH:20][CH:19]=1>>[CH:18]1[C:28]2[CH2:27][CH2:26][C:25]3[CH:29]=[CH:30][CH:31]=[CH:32][C:24]=3[CH:23]([N:33]3[CH2:38][CH2:37][CH:36]([CH2:39][CH2:40][CH2:41][CH2:42][NH:43][C:9](=[O:11])[CH:8]=[CH:7][C:3]4[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=4)[CH2:35][CH2:34]3)[C:22]=2[CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 65578Oxalyl chlorideHCID 1019843-(3-Pyridinyl)-2-propenoic acidHCID 15390853HCID 15390853, compound

Product 1

HCID 54045789HCID 54045789, compound

Procedure

Batch size: 2.6 g (17.6 mmol) 3-(3-pyridyl)-acrylic acid, 2.6 g (20.8 mmol) oxalyl chloride and 5.57 g (16.0 mmol) 4-[1-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-yl)-piperidin-4-yl]-butylamine.

Sources & evidence

ORD record
ord-f22e1d1715f84d6fa2b061e0c0b44100
Source dataset
uspto-grants-2002_09
Patent number
US06451816B1

Reaction notes

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