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HRID1280807

反应详情

EQUATION

反应方程式

HRID 1280807 的结构方程式

REACTANTS

反应物

4
结构：O=CC(O)CO
HCID751

(+/-)-Glyceraldehyde

C3H6O3

结构：[BH3-]C#N.[Na+]
HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

结构：c1ccc(COC[C@H]2NC[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)cc1
HCID22842874

未命名化合物

2 次

结构：CCCCN1C[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1COCc1ccccc1
HCID53802070

未命名化合物

PRODUCTS

生成物

1
结构：OCC(O)CN1C[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1COCc1ccccc1
HCID54393635

未命名化合物

收率 72%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

The title compound was synthesized as described for compound 10 using (2R,3R,4R)-3,4-dibenzyloxy-2-benzyloxymethylpyrrolidine (Compound 1) (0.5 g, 1.2 mmol), methanol (30 ml), glyceraldehyde (0.134 g, 1.5 mmol) and sodium cyanoborohydride (0.094 g, 1.5 mmol). Purification of the crude product on silica gel (Eluent: Ethyl acetate) afforded (2R,3R,4R)-3,4-dibenzyloxy-2-benzyloxymethyl-1-(2,3-dihydroxyprop-1-yl)pyrrolidine (0.424 g, yield: 72%) as an oil.

WORKUP

后处理

  1. customThe title compound was synthesized
  2. customPurification of the crude product on silica gel (Eluent: Ethyl acetate)