反应详情

A mixture of 17 g. of 3-tosyloxy-1,2,3,4-tetrahydrocarbazole and 25 g. of 40% methylamine in 200 ml. of 2-ethoxyethanol containing 5 g. of sodium bicarbonate was heated on a steam bath for one hour then left standing overnight at room temperature. The solvent was removed by distillation and the residue taken up in ether and the mixture filtered. Evaporation of the filtrate gave a residue which crystallized upon trituration with ether. The 3-(methylamino)-1,2,3,4-tetrahydrocarbazole thus obtained melted at 134°-136° C. (corr.).

1. additionA mixture of 17 g
2. waitthen left
3. customThe solvent was removed by distillation
4. filtrationthe mixture filtered
5. customEvaporation of the filtrate
6. customgave a residue which
7. customcrystallized upon trituration with ether