Piperidine → 4-[[N-(2-amino-5-trifluoromethylbenzoyl)glycyl]aminomethyl]piperidine

HRID 1281021Notes

Reaction equation

HRID 1281021 reaction equation
NC1C=C(F)C(F)=CC=1C(NCC(NCC1CCNCC1)=O)=O.C(OC(NC1C=CC(OC(F)(F)F)=CC=1C(NCC(NCC1CCNCC1)=O)=O)=O)(C)(C)C.N1CCCCC1.C(OC([NH:70][C:71]1[CH:90]=[CH:89][C:88]([C:91]([F:94])([F:93])[F:92])=[CH:87][C:72]=1[C:73]([NH:75][CH2:76][C:77]([NH:79][CH2:80][CH:81]1[CH2:86][CH2:85][NH:84][CH2:83][CH2:82]1)=[O:78])=[O:74])=O)(C)(C)C>>[NH2:70][C:71]1[CH:90]=[CH:89][C:88]([C:91]([F:94])([F:92])[F:93])=[CH:87][C:72]=1[C:73]([NH:75][CH2:76][C:77]([NH:79][CH2:80][CH:81]1[CH2:82][CH2:83][NH:84][CH2:85][CH2:86]1)=[O:78])=[O:74]

Participants

5

Reactant 4

HCID 8082PiperidineHCID 184261764-[{(N-(2-Amino-4,5-difluorobenzoyl)glycyl)amino}methyl]piperidineHCID 184262254-[{(N-(2-(tert-butoxycarbonylamino)-5-trifluoromethylbenzoyl)glycyl)amino}methyl]piperidineHCID 184262354-[{N-(2-(tert-butoxycarbonylamino)-5-trifluoromethoxybenzoyl)glycyl}aminomethyl]piperidine

Product 1

HCID 184262274-[[N-(2-amino-5-trifluoromethylbenzoyl)glycyl]aminomethyl]piperidine

Procedure

4-[{(N-(2-Amino-4,5-difluorobenzoyl)glycyl)amino}methyl]piperidine, 4-[{N-(2-(tert-Butoxycarbonylamino)-5-trifluoromethoxybenzoyl)glycyl}aminomethyl]piperidine, 4-[{N-(2-(tert-butoxycarbonylamino)-4,5-difluorobenzoyl)glycyl)amino}methyl]piperidine, and 4-[{(N-(2-(tert-butoxycarbonylamino)-5-trifluoromethylbenzoyl)glycyl)amino}methyl]piperidine were also prepared pursuant to the above method using the corresponding reactant, respectively.

Sources & evidence

ORD record
ord-523888255d644986a5601d4407ac1a9f
Source dataset
uspto-grants-2002_09
Patent number
US06451842B1

Reaction notes

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