N,N-Dimethylethylenediamine → HCID 22664376, compound

HRID 1281069Notes

Reaction equation

HRID 1281069 reaction equation
[OH:1][C:2]1[C:7]([C:8]([C:11]2[CH:16]=[CH:15][C:14]([S:17](Cl)(=[O:19])=[O:18])=[CH:13][CH:12]=2)([CH3:10])[CH3:9])=[CH:6][C:5]([C:21]([CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:23])[CH3:22])=[CH:4][C:3]=1[N:29]1[N:33]=[C:32]2[CH:34]=[CH:35][CH:36]=[CH:37][C:31]2=[N:30]1.[CH3:38][N:39]([CH3:43])[CH2:40][CH2:41][NH2:42]>>[OH:1][C:2]1[C:7]([C:8]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([NH:42][CH2:41][CH2:40][N:39]([CH3:43])[CH3:38])(=[O:19])=[O:18])=[CH:13][CH:12]=2)([CH3:10])[CH3:9])=[CH:6][C:5]([C:21]([CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:23])[CH3:22])=[CH:4][C:3]=1[N:29]1[N:33]=[C:32]2[CH:34]=[CH:35][CH:36]=[CH:37][C:31]2=[N:30]1

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 22664396HCID 22664396, compound

Product 1

HCID 22664376HCID 22664376, compound

Procedure

The title compound is prepared according to the procedure given in instant Example 35 using 8.0 g of the intermediate compound prepared in Example 34a and 1.4 g of 2-dimethylaminoethylamine. After several recrystallizations from ethyl acetate and ethyl acetate/heptane mixtures, 5.6 g of the title compound is prepared as a near white solid melting at 118-120° C. The structure of the compound is confirmed by 1Hnmr and mass spectroscopy analyses.

Workup

  1. customAfter several recrystallizations from ethyl acetate and ethyl acetate/heptane mixtures, 5.6 g of the title compound
  2. customis prepared as a near white solid melting at 118-120° C

Sources & evidence

ORD record
ord-22a10c0f50cf46a0b05cafcc1896c46a
Source dataset
uspto-grants-2002_09
Patent number
US06451887B1

Reaction notes

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