Hydrochloric Acid → HCID 15516358, compound

HRID 1281094Notes

Reaction equation

HRID 1281094 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH2:14][CH2:13][C:12](=[O:15])[NH:11][C:10]2=[O:16])[CH:5]=[CH:6][C:7]=1[Cl:8].CO.[NH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1.Cl>O>[C:10]([C:9]([C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)([CH2:14][CH2:13][C:12]([N:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:15])[CH2:17][CH2:18][C:19]([OH:21])=[O:20])(=[O:16])[NH2:11]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 8082PiperidineHCID 11121055HCID 11121055, compound

Product 1

HCID 15516358HCID 15516358, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.3 g of racemic 3-[3-(3,4-dichlorophenyl)-2,6-dioxopiperidin-3-yl]propionic acid, 1 ml of methanol and 0.5 ml of piperidine are placed at 60° C. for 15 hours in a round-bottomed flask. The reaction medium is diluted with 10 ml of water and acidified with 1 N HCl to pH 2-3. The white crystals formed are filtered, drained and then dried to give 0.3 g of the expected compound.

Workup

  1. customThe white crystals formed
  2. filtrationare filtered
  3. customdried

Sources & evidence

ORD record
ord-f7a1de92b37a4bddbab8ef68481ad4d7
Source dataset
uspto-grants-2002_09
Patent number
US06452012B1

Reaction notes

Loading…