反应详情

To a solution of 2-bromo-5-pyridinecarboxaldehyde (1.02 g, 5.48 mmol) in methanol (100 mL) was added p-toluenesulfonic acid hydrate (1.05 g, 5.53 mmol), and the mixture was heated at reflux for 1.5 h. Diluted aqueous sodium bicarbonate was added, and the mixture was extracted with ethyl acetate twice. The organic layer was washed with brine and dried on anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to afford 2-bromo-5-dimethoxymethylpyridine (1.19 g, 94%) as an oil.

1. temperaturethe mixture was heated
2. temperatureat reflux for 1.5 h
3. extractionthe mixture was extracted with ethyl acetate twice
4. washThe organic layer was washed with brine
5. dry with materialdried on anhydrous sodium sulfate
6. customThe solvent was evaporated under reduced pressure