反应详情

温度

0 °C

There are added to a suspension of 12.3 g of nicotinic acid in 100 ml of dimethylformamide 14.2 ml of triethylamine and then, after cooling to 0° C., 22 ml of diphenylphosphoryl azide in 50 ml of dimethylformamide. After stirring for 2 hours, the reaction mixture is poured onto ice. After extraction with ether, the organic phase is washed with a NaHCO3 solution, dried, and then concentrated to yield 9.68 g of the expected product.

1. additionthe reaction mixture is poured onto ice
2. extractionAfter extraction with ether
3. washthe organic phase is washed with a NaHCO3 solution
4. customdried
5. concentrationconcentrated