Acetic Acid → HCID 86746863, compound

HRID 1281206Notes

Reaction equation

HRID 1281206 reaction equation
[F:1][C:2]([F:44])([CH2:40][CH2:41][CH2:42][CH3:43])[C:3](=[O:39])[CH2:4][CH2:5][C@H:6]1[C@H:10]([O:11]C2CCCCO2)[CH2:9][C:8](=[O:18])[C@H:7]1[CH2:19]/[CH:20]=[CH:21]\[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([O:29][CH2:30][C:31]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:32])=[O:28].C(O)(=O)C.O>C1COCC1>[F:1][C:2]([F:44])([CH2:40][CH2:41][CH2:42][CH3:43])[C:3](=[O:39])[CH2:4][CH2:5][C@H:6]1[C@H:10]([OH:11])[CH2:9][C:8](=[O:18])[C@@H:7]1[CH2:19]/[CH:20]=[CH:21]\[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([O:29][CH2:30][C:31]([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)=[O:32])=[O:28]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 962WaterHCID 131722603HCID 131722603, compound

Product 1

HCID 86746863HCID 86746863, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The compound (16-a)(0.514 g) was dissolved in the solvent mixture (acetic acid:water:THF=4:2:1)(30 ml), and the solution was maintained overnight at room temperature. The titled compound (16-b) was obtained by purifying the crude product on silica gel column [yield:0.272 g(61%)].

Sources & evidence

ORD record
ord-cb5d905d62624077a8939a8ff49bf356
Source dataset
uspto-grants-2002_09
Patent number
US06452039B1

Reaction notes

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