HCID 131722604, compound → HCID 70148109, compound

HRID 1281209Notes

Reaction equation

HRID 1281209 reaction equation
[O:1]([CH:9]([C:39]([F:47])([F:46])[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])[CH2:10][CH2:11][C@H:12]1[C@H:16]([O:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)[CH2:15][C@@H:14]([OH:24])[CH:13]1[CH2:25]/[CH:26]=[CH:27]\[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]([O:35][CH:36]([CH3:38])[CH3:37])=[O:34])[Si:2]([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3]>C(OCC)(=O)C.[Pd]>[O:1]([CH:9]([C:39]([F:47])([F:46])[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])[CH2:10][CH2:11][C@H:12]1[C@H:16]([O:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)[CH2:15][C@@H:14]([OH:24])[CH:13]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]([O:35][CH:36]([CH3:37])[CH3:38])=[O:34])[Si:2]([C:5]([CH3:7])([CH3:8])[CH3:6])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 131722604HCID 131722604, compound

Product 1

HCID 70148109HCID 70148109, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The compound (12-9)(1.39 g) was subjected to catalytic reduction in ethyl acetate (15 ml) using 5% Pd—C (0.14 g) under hydrogen atmosphere. The crude product obtained by the conventional treatment was purified by silica gel chromatography (n-hexane/ethyl acetate=8/2) to give the titled compound (12-10).

Workup

  1. customThe crude product obtained by the conventional treatment
  2. customwas purified by silica gel chromatography (n-hexane/ethyl acetate=8/2)

Sources & evidence

ORD record
ord-bcd0bc172163418bb503815b5c9f9a52
Source dataset
uspto-grants-2002_09
Patent number
US06452039B1

Reaction notes

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