反应详情

温度

-72 °C

A solution of 0.912 grams of 2,6-dichlorobenzamide in 75 ml. of dry tetrahydrofuran was placed in a 3-necked, 250 ml. round bottomed flask. The solution was cooled to about -72° C. with a dry ice/acetone bath. To the mixture was added 1.8 ml. of n-butyllithium solution over a 5-minute period. The mixture was allowed to stand for 30 minutes at -75° C. to -70° C. A solution of 0.804 grams of 4-nitrophenyl chloroformate in 24 ml. of dry tetrahydrofuran was added over a period of 30 minutes at about -72° C. The mixture was allowed to stand an additional 30 minutes in the cold at which time it became colorless. The solution was warmed to -40° C. and held at that temperature for 2.75 hours. The mixture was cooled again to about -72° C. and a solution of 0.64 grams of 3-aminobenzotrifluoride in 25 ml. of dry tetrahydrofuran was added over 10 minutes. The solution was allowed to warm to room temperature and was then heated at 50° C. for 16 hours. The solvent was removed and the residue was dissolved in 10 ml. of ether. The solution was washed with 1 N sodium carbonate solution, dried over magnesium sulfate and the solvent again removed. The residue was triturated under ether to give 0.6 grams of a white crystalline solid melting above 200° C.

1. additionTo the mixture was added 1.8 ml
2. waitto stand an additional 30 minutes in the cold at which time it
3. temperatureThe solution was warmed to -40° C.
4. waitheld at that temperature for 2.75 hours
5. temperatureThe mixture was cooled again to about -72° C.
6. temperatureto warm to room temperature
7. temperaturewas then heated at 50° C. for 16 hours
8. customThe solvent was removed
9. dissolutionthe residue was dissolved in 10 ml
10. washThe solution was washed with 1 N sodium carbonate solution
11. dry with materialdried over magnesium sulfate
12. customthe solvent again removed
13. customThe residue was triturated under ether