Lithium Hydroxide → HCID 10304359, compound

HRID 1281590Notes

Reaction equation

HRID 1281590 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[CH2:14][NH:15][C:16]([N:18]1[CH2:23][CH2:22][CH:21]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][NH:33][CH2:34][C@H:35]([OH:45])[CH2:36][O:37][C:38]3[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][CH:39]=3)=[CH:27][CH:26]=2)[CH2:20][CH2:19]1)=[O:17])[O:5][CH2:6][C:7]([O:9]C)=[O:8].[Li+].[OH-]>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[CH2:14][NH:15][C:16]([N:18]1[CH2:19][CH2:20][CH:21]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][NH:33][CH2:34][C@H:35]([OH:45])[CH2:36][O:37][C:38]3[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][CH:39]=3)=[CH:27][CH:26]=2)[CH2:22][CH2:23]1)=[O:17])[O:5][CH2:6][C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 69987239HCID 69987239, compound

Product 1

HCID 10304359HCID 10304359, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methyl 2-(3-fluoro-4-{[({4-[4-(2-{[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino}ethyl)anilino]-1-piperidinyl}carbonyl)amino]methyl}phenoxy)acetate (0.107 g, 0.2 mmol) was dissolved in tetrahydrofuran. To this solution was added 1N LiOH (2 mL, 0.2 mmol) and stirred at ambient temperature for four days. The solvent was removed in vacuo and the resulting solid lyophilized to yield the title compound (0.075 g, 0.1 mmol).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-2e665e36771d4fc38410a49bf608a5d9
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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