反应详情

To a mixture of 68.5 g of p-chlorobenzonitrile and 24.0 g. of sodium hydride (50% in mineral oil) in 250 ml. of ether is added, 26.1 ml. of acetonitrile and 2 ml. of isopropanol. The mixture is stirred and refluxed on a steam bath for 6 hours and then stirred overnight at room temperature. A 5 ml. portion of methanol and 250 ml. of water are added. The ether is boiled away on a steam bath and the mixture is filtered. The solid is dissolved in warm ethyl acetate and filtered. The filtrate is evaporated to a solid giving β-amino-4-chlorocinnamonitrile.

1. temperaturerefluxed on a steam bath for 6 hours
2. stirringstirred overnight at room temperature
3. filtrationthe mixture is filtered
4. dissolutionThe solid is dissolved in warm ethyl acetate
5. filtrationfiltered
6. customThe filtrate is evaporated to a solid