Sodium Hydroxide → 2-Hydroxy-3-nitrobenzenecarbohydrazide

HRID 1281659Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1281659
O.[NH2:2][NH2:3].[N+:4]([C:7]1[CH:16]=[CH:15][CH:14]=[C:9]([C:10](OC)=[O:11])[C:8]=1[OH:17])([O-:6])=[O:5].[OH-].[Na+]>O1CCCC1>[OH:17][C:8]1[C:7]([N+:4]([O-:6])=[O:5])=[CH:16][CH:15]=[CH:14][C:9]=1[C:10]([NH:2][NH2:3])=[O:11]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 596904Methyl 2-hydroxy-3-nitrobenzoate

Produkt 1

HCID 113676062-Hydroxy-3-nitrobenzenecarbohydrazideAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

40 ml of hydrazine hydrate were added to a solution of 30 g (0.15 mol) of methyl 3-nitrosalicylate in 200 ml of anhydrous tetrahydrofuran (THF). After dilution with THF, the resulting suspension was stirrable; it was refluxed for approximately 18 hours. After cooling, the batch was poured onto ice. The aqueous solution was rendered neutral by adding NaOH solution. The crystals which precipitated were filtered off and washed with water. After drying, 27 g (90%) of the title compound were obtained.

Aufarbeitung

  1. temperatureit was refluxed for approximately 18 hours
  2. temperatureAfter cooling
  3. additionthe batch was poured onto ice
  4. customThe crystals which precipitated
  5. filtrationwere filtered off
  6. washwashed with water
  7. customAfter drying

Quellen und Nachweise

ORD-Eintrag
ord-be80d6a2740b47469a8435481c37587a
Quelldatensatz
uspto-grants-2002_09
Patentnummer
US06455515B2

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