Oxalyl chloride → HCID 18422067, compound

HRID 1281731Notes

Reaction equation

HRID 1281731 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[CH:7]([N:10]1[CH2:15][CH2:14][CH:13]([O:16][C:17]2[CH:18]=C([CH:23]=[CH:24][CH:25]=2)C(O)=O)[CH2:12][CH2:11]1)([CH3:9])[CH3:8]>CN(C=O)C.C(Cl)Cl>[CH:7]([N:10]1[CH2:11][CH2:12][CH:13]([O:16][C:17]2[CH:18]=[C:1]([CH:23]=[CH:24][CH:25]=2)[C:2]([Cl:4])=[O:3])[CH2:14][CH2:15]1)([CH3:9])[CH3:8]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 18422106HCID 18422106, compound

Product 1

HCID 18422067HCID 18422067, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (0.34 ml) was added to a stirred mixture of 3-(N-isopropylpiperidin-4-yloxy)benzoic acid (0.782 g), DMF (2 drops) and methylene chloride (20 ml) which had been cooled in an ice bath. The resultant mixture was stirred at ambient temperature for 4 hours. The mixture was evaporated and the 3-(N-isopropylpiperidin-4-yloxy)benzoyl chloride so obtained was dissolved in methylene chloride (20 ml).

Workup

  1. temperaturehad been cooled in an ice bath
  2. customThe mixture was evaporated

Sources & evidence

ORD record
ord-af7f3a3e035648379de8a742f94880ab
Source dataset
uspto-grants-2002_09
Patent number
US06455520B1

Reaction notes

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