1,2-Dichloroethane → HCID 70095509, compound

HRID 1281749Notes

Reaction equation

HRID 1281749 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.C[CH:17]([CH:21]([CH2:25][CH:26]([CH3:28])[CH3:27])[C:22]([OH:24])=[O:23])[C:18](O)=[O:19].[CH2:29](Cl)CCl>ClCCl>[CH3:29][O:24][C:22](=[O:23])[CH:21]([CH2:17][C:18]([N:11]1[CH2:12][CH2:13][CH:8]([C:6](=[O:7])[C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:15][CH:14]=2)[CH2:9][CH2:10]1)=[O:19])[CH2:25][CH:26]([CH3:28])[CH3:27]

Participants

5

Reactant 3

HCID 111,2-DichloroethaneHCID 27771154-(4-Chlorobenzoyl)PiperidineHCID 18423337HCID 18423337, compound

Product 1

HCID 70095509HCID 70095509, compoundYield 79.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(4-Chlorobenzoyl)piperidine (0.2 g) was added to a solution of methyl 3-isobutylsuccinic acid (0.15 g) and EDC (0.25 g) in dichloromethane (10 ml) and the solution was stirred for 18 h, then washed with water (10 ml), aqueous citric acid (10 ml), saturated sodium bicarbonate (10 ml) and brine (10 ml), dried over magnesium sulphate (1 g) and evaporated to give the title compound (0.25 g) as a colourless solid.

Workup

  1. washwashed with water (10 ml), aqueous citric acid (10 ml), saturated sodium bicarbonate (10 ml) and brine (10 ml)
  2. dry with materialdried over magnesium sulphate (1 g)
  3. customevaporated

Sources & evidence

ORD record
ord-3afa5b5e40e3485fa844695a14319557
Source dataset
uspto-grants-2002_09
Patent number
US06455531B1

Reaction notes

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