Chlorosuccinimide → HCID 18422325, compound

HRID 1281830Notes

Reaction equation

HRID 1281830 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[C:14]([N:15]4[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]4)=[N:13][C:12]4[CH:22]=[CH:23][C:24]([CH3:26])=[CH:25][C:11]=4[NH:10][C:9]=3[S:27][C:4]=2[CH:3]=1.[Cl:28]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Cl:28][CH2:26][C:24]1[CH:23]=[CH:22][C:12]2[N:13]=[C:14]([N:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]3)[C:8]3[C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=4[S:27][C:9]=3[NH:10][C:11]=2[CH:25]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 18422149HCID 18422149, compound

Product 1

HCID 18422325HCID 18422325, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

3-Fluoro-8-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is dissolved in carbon tetrachloride and reacted with 2,2′-azobis(isobutylonitrile) in the presence of N-chlorosuccinimide to give 8-chloromethyl-3-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine.

Sources & evidence

ORD record
ord-0f29812b40ca4401905450bf6a11c400
Source dataset
uspto-grants-2002_09
Patent number
US06455521B1

Reaction notes

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