反应详情

0.5 g (1.85 mmol) of 2-(4-{[(2-chloroethoxy)carbonyl]amino}phenyl)propanoic acid were dissolved in 10 ml of N,N-dimethylformamide and 0.45 g (3.7 mmol) of potassium carbonate were added. After 48 hours the solvent was evaporated under vacuum, the residue redissolved with dichloromethane and washed with hydrochloric acid 0.5 N. The organic layer was dried over sodium sulphate and evaporated. 0.35 g (80% yield) of the title compound crystallized from a mixture ethylacetate-diisopropylether.

1. customAfter 48 hours the solvent was evaporated under vacuum
2. dissolutionthe residue redissolved with dichloromethane
3. washwashed with hydrochloric acid 0.5 N
4. dry with materialThe organic layer was dried over sodium sulphate
5. customevaporated