Piperazine → 1-(4-Pyridyl)piperazine

HRID 1282143Notes

Reaction equation

HRID 1282143 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1>O>[N:11]1[CH:12]=[CH:13][C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 142684-Bromopyridine

Product 1

HCID 705171-(4-Pyridyl)piperazineYield 62%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
145 °C

Procedure

To piperazine (3.6 g) dissolved at 110° C. was added 4-bromopyridine (1.0 g) and the mixture was stirred at 140-150° C. for 1 hr. The reaction mixture was poured into water and extracted with chloroform. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (0.64 g) as a pale-yellow solid.

Workup

  1. extractionextracted with chloroform
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated

Sources & evidence

ORD record
ord-75d4c725fe7548b2b2902fe8bd3c0696
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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