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0 °C

2.2 g of silver oxide were added to a mixture of 4.6 g of 3-(m-trifluoromethylphenyl)-piperidine and 22 ml of acetone and the mixture was cooled on an ice water bath while 2.55 ml (≃3.6 g) of benzyl bromide was added dropwise over 10 minutes at a temperature less than 10° C. The mixture was stirred at 0° C. for one hour and was filtered. The filtrate was evaporated to dryness under reduced presssure to obtain 7 g of raw product which was chromatographed over silica gel. Elution with an 85-10-5 cyclohexane-chloroformtriethylamine mixture and evaporation to dryness under reduced pressure yielded 4.99 g of N-benzyl-3-(m-trifluoromethylphenyl)-piperidine.

1. additionwas added dropwise over 10 minutes at a temperature less than 10° C
2. filtrationwas filtered
3. customThe filtrate was evaporated to dryness under reduced presssure
4. customto obtain 7 g of raw product which
5. customwas chromatographed over silica gel
6. washElution
7. customwith an 85-10-5 cyclohexane-chloroformtriethylamine mixture and evaporation to dryness under reduced pressure