Imidazole → HCID 23469000, compound

HRID 128237Notes

Reaction equation

HRID 128237 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[NH:6][CH:7]=[CH:8][CH:9]=1)[CH3:3].[NH:10]1C=CN=[CH:11]1>C1(C)C(C)=CC=CC=1>[N:2]1([CH2:4][C:5]2[NH:6][CH:7]=[CH:8][CH:9]=2)[CH:3]=[CH:11][N:10]=[CH:1]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 260796N,N-dimethyl-1-(1H-pyrrol-2-yl)methanamine

Product 1

HCID 23469000HCID 23469000, compoundYield 52.1%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 2-(dimethylaminomethyl)pyrrole (24.8 g) and imidazole (13.6 g) in xylene (120 ml) are heated under reflux for 3 hours. The solution was cooled and the solid was filtered off and crystallised from ether to give 2-(imidazol-1-ylmethyl) pyrrole (15.3 g), m.p. 89°-90°, raised to 91°-92° on further crystallisation from water.

Workup

  1. temperatureunder reflux for 3 hours
  2. temperatureThe solution was cooled
  3. filtrationthe solid was filtered off
  4. customcrystallised from ether

Sources & evidence

ORD record
ord-a8d1fca8ea0a4ed1be314a99f5070d04
Source dataset
uspto-grants-1981_03
Patent number
US04259345

Reaction notes

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