反应详情

温度

60 °C

A mixture of 4-(2-chloro-5-trifluoromethylphenyl)-1-fluoro-2-fluoromethyl-3-cis-buten-2-ol (8.80 g), potassium tert-butoxide (3.50 g) and N,N-dimethylformamide (60 ml) was stirred at 60° C. for 40 minutes. To the reaction mixture, 2 N HCl was added, followed by extraction with ethyl acetate; the resulting organic layers were combined, washed with a saturated aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 2,2-bis(fluoromethyl)-6-trifluoromethyl-2H-1-benzopyran (7.0 g).

1. extractionfollowed by extraction with ethyl acetate
2. washwashed with a saturated aqueous solution of sodium bicarbonate
3. dry with materiala saturated aqueous solution of sodium chloride, dried with anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure