反应详情

An amount (1.2 g) of 1-fluoro-2-fluoromethyl-3-butyn-2-ol and methanesulfonyl chloride (0.85 ml) were dissolved in tert-butyl methyl ether (15 ml); to the solution under cooling with ice, triethylamine (1.5 ml) was added dropwise in a nitrogen atmosphere. After stirring for 1.5 hours under cooling with ice, tert-butyl methyl ether was added to the reaction mixture, which was then washed with water and a saturated aqueous solution of sodium chloride. The mixture was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the titled compound (1.9 g).

1. additionwas added dropwise in a nitrogen atmosphere
2. additionwas added to the reaction mixture, which
3. washwas then washed with water
4. dry with materialThe mixture was dried with anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure