2-Aminopyridine → HCID 20158054, compound

HRID 1282722Notes

Reaction equation

HRID 1282722 reaction equation
[CH2:1]([C:8]1[C:9](=O)[O:10][C:11]([CH3:15])=[CH:12][C:13]=1[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1C=CC=CN=1.Cl.[NH2:25][OH:26]>>[OH:26][N:25]1[C:11]([CH3:15])=[CH:12][C:13]([CH3:14])=[C:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9]1=[O:10]

Participants

4

Reactant 3

HCID 104392-AminopyridineHCID 443297Hydroxyamine hydrochlorideHCID 21520171HCID 21520171, compound

Product 1

HCID 20158054HCID 20158054, compoundYield 30.4%

Procedure

2 g of 3-benzyl-4,6-dimethyl-2-pyrone, 6 g of 2-aminopyridine and 1 g of hydroxylamine-hydrochloride were heated for 8 hours to 70° C. After working up as described in Example 1, 0.65 g (30%) of 1-hydroxy-3-benzyl-4,6-dimethyl-2-pyridone were obtained; melting point 148° C (Calc.: 6.1 % N, found 6.1 % N).

Sources & evidence

ORD record
ord-6c766eb7a64649babd9a8a242d6802df
Source dataset
uspto-grants-1976_08
Patent number
US03972888

Reaction notes

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