Methyl Isocyanate → HCID 131710414, compound

HRID 1282913Notes

Reaction equation

HRID 1282913 reaction equation
[C:1]([C:5]1[NH:9][C:8]([S:10]([N:13]([CH3:15])[CH3:14])(=[O:12])=[O:11])=[N:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:16][N:17]=[C:18]=[O:19]>C(N(CC)CC)C>[CH3:16][NH:17][C:18]([N:7]1[C:8]([S:10]([N:13]([CH3:15])[CH3:14])(=[O:12])=[O:11])=[N:9][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[N:6]1)=[O:19]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 178486157HCID 178486157, compound

Product 1

HCID 131710414HCID 131710414, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A solution of 8.0 g (0.034 mols) of 3-tert.butyl-4H-1,2,4-triazol-5-yl-N,N-dimethylsulfonamide and 3.4 g (0.06 mol) of methyl isocyanate in 20 ml of triethylamine is stirred overnight at room temperature. The solvent is evaporated under vacuum and the residue is slurried in water. The resultant solid is collected by filtration and recrystallized from ethanol to give 1-N-methylcarbamyl-3-tert.butyl-1,2,4-triazol-5-yl-N,N-dimethylsulfonamide, m.p. 193°-194.5°.

Workup

  1. customThe solvent is evaporated under vacuum
  2. filtrationThe resultant solid is collected by filtration
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-01e26e29897e43c7a83026d8cf2312c3
Source dataset
uspto-grants-1976_08
Patent number
US03973028

Reaction notes

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