Ethyl Thioglycolate → HCID 21519310, compound

HRID 1283086Notes

Reaction equation

HRID 1283086 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[N:3]=1.[SH:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21].C(=O)(O)[O-].[Na+]>C(O)C>[CH2:23]([O:22][C:20](=[O:21])[CH2:19][S:18][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[N:3]=1)[CH3:24]

Participants

5

Reactant 3

HCID 12185Ethyl ThioglycolateHCID 516892Sodium BicarbonateHCID 21519305HCID 21519305, compound

Product 1

HCID 21519310HCID 21519310, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred mixture of 3.25 g. of 4,6-dichloro-2-(p-chlorobenzylamino)pyrimidine, 1.35 g. of ethyl mercaptoacetate and 0.95 g. of sodium bicarbonate in 50 ml. of ethanol was heated under reflux overnight. The reaction mixture was filtered. A crystalline material was deposited which amounted to 2.7 g., m.p. 122°-125°C. The analytical sample was obtained by recrystallization from ethanol, m.p. 122°-125°C.

Workup

  1. additionA stirred mixture of 3.25 g
  2. temperatureunder reflux overnight
  3. filtrationThe reaction mixture was filtered
  4. customThe analytical sample was obtained by recrystallization from ethanol, m.p. 122°-125°C.

Sources & evidence

ORD record
ord-61ce46c11c3d414c83b52090ac1c4e60
Source dataset
uspto-grants-1976_08
Patent number
US03974162

Reaction notes

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