Allyl glycidyl ether → 1-Allyloxy-3-n-propylamino-2-propanol

HRID 1283102Notes

Reaction equation

HRID 1283102 reaction equation
[CH2:1]([O:4][CH2:5][CH:6]1[O:8][CH2:7]1)[CH:2]=[CH2:3].[CH2:9]([NH2:12])[CH2:10][CH3:11]>C(O)C>[CH2:1]([O:4][CH2:5][CH:6]([OH:8])[CH2:7][NH:12][CH2:9][CH2:10][CH3:11])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 7838Allyl glycidyl etherHCID 7852Propylamine

Product 1

HCID 214303991-Allyloxy-3-n-propylamino-2-propanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Allylglycidyl ether (94.7 g.) is added with stirring to a solution of n-propylamine (98 g., 137 ml.) in ethanol (200 ml.). The mixture is heated under reflux for 18 hours and the solvent and excess of n-propylamine are distilled off. The residual oil is distilled and the fraction b.p. 79°-85°C. at 1 m.m. is collected to give 1-allyloxy-3-n-propylamino-2-propanol.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 18 hours
  3. distillationthe solvent and excess of n-propylamine are distilled off
  4. distillationThe residual oil is distilled
  5. customis collected

Sources & evidence

ORD record
ord-1a017ccbe05f4f37a82767091b1681d6
Source dataset
uspto-grants-1976_08
Patent number
US03974158

Reaction notes

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