Methyl iodide → HCID 21519274, compound

HRID 1283130Notes

Reaction equation

HRID 1283130 reaction equation
[CH3:1][N:2]([CH3:19])[CH2:3][CH:4]([C:6]1([OH:18])[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:5].[CH3:20][I:21]>CCOCC.O1CCCC1>[I-:21].[OH:18][C:6]1([CH:4]([CH3:5])[CH2:3][N+:2]([CH3:20])([CH3:1])[CH3:19])[CH2:11][CH2:10][CH2:9][CH2:8][CH:7]1[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 21519258HCID 21519258, compound

Product 1

HCID 21519274HCID 21519274, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3.5 grams of 1-(2-dimethylamino-1-methylethyl)-2-phenyl-cyclohexanol in 250 ml ether and 10 ml tetrahydrofuran is treated with 6 ml methyl iodide and allowed to stand for 7 days. The crystalline product is filtered and washed with ether and recrystallized from water giving 2.1 grams melting at 155°-159°C.

Workup

  1. filtrationThe crystalline product is filtered
  2. washwashed with ether
  3. customrecrystallized from water giving 2.1 grams melting at 155°-159°C.

Sources & evidence

ORD record
ord-d523010a4cd2450b9bdfb6ac860fadda
Source dataset
uspto-grants-1976_08
Patent number
US03974157

Reaction notes

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