Acetyl chloride → HCID 68139952, compound

HRID 1283141Notes

Reaction equation

HRID 1283141 reaction equation
Cl.[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C:17]2([CH:23]([CH3:28])[CH2:24][N:25]([CH3:27])[CH3:26])[OH:22])=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[C:35](Cl)(=[O:37])[CH3:36]>C(Cl)(Cl)Cl>[C:35]([O:22][C:17]1([CH:23]([CH3:28])[CH2:24][N:25]([CH3:26])[CH3:27])[CH2:18][CH2:19][CH2:20][CH2:21][CH:16]1[C:13]1[CH:14]=[CH:15][C:10]([O:9][CH2:2][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)=[CH:11][CH:12]=1)(=[O:37])[CH3:36]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 11430Potassium CarbonateHCID 21519282HCID 21519282, compound

Product 1

HCID 68139952HCID 68139952, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2-(p-Benzyloxyphenyl)-1-(2-dimethylamino-1-methylethyl)cyclohexanol hydrochloride (11.3 g) is stirred with 140 ml chloroform and 26 g potassium carbonate. Acetyl chloride (6.5 ml) is added and the mixture is stirred overnight, washed with water, and the chloroform dried. The chloroform solution is stirred for 6 hours with 6.5 ml acetyl chloride and 26 g potassium carbonate, then washed with water, dried and concentrated to give 14 g crude product.

Workup

  1. washwashed with water
  2. dry with materialthe chloroform dried
  3. stirringThe chloroform solution is stirred for 6 hours with 6.5 ml acetyl chloride and 26 g potassium carbonate
  4. washwashed with water
  5. customdried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-0563ec673fda4a74a2a2da71ee7c3a4e
Source dataset
uspto-grants-1976_08
Patent number
US03974157

Reaction notes

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