反应详情

Piperidine (2.1 g., 0.0237 mole) and 2-cyanoacetamide (22.0 g., 0.263 mole) are added to a slurry of 6-nitroveratraldehyde (50.0 g., 0.237 mole) in methanol (500 ml.). The mixture is heated to reflux for 2 hours, and then cooled in an ice bath and filtered. The bright yellow filter cake is washed with cold isopropanol (300 ml.) and then air dried. Yield = 60.1 g. (93%); m.p. 265°-266° C.

1. temperatureThe mixture is heated
2. temperatureto reflux for 2 hours
3. temperaturecooled in an ice bath
4. filtrationfiltered
5. washThe bright yellow filter cake is washed with cold isopropanol (300 ml.)
6. customair dried