Hydrochloric Acid → HCID 86733820, compound

HRID 1283240Notes

Reaction equation

HRID 1283240 reaction equation
O=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([Cl:12])[C:9]=2[Cl:11])[CH2:4][C:3]1([CH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1)[CH3:18].Cl.[OH:25][NH2:26].Cl>N1C=CC=CC=1>[OH:25][N:26]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[C:8]([Cl:12])[C:9]=2[Cl:11])[CH2:4][C:3]1([CH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1)[CH3:18]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3667[(6,7-Dichloro-2-cyclopentyl-2-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]acetic acidHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 86733820HCID 86733820, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A stirred solution of (1-oxo-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid (5.1 g., 0.015 mole) and hydroxyamine hydrochloride (3.2 g., 0.045 mole) in pyridine (60 ml.) is heated at 95°C. on a steam bath for 40 hours then poured into aqueous hydrochloric acid affording (1-hydroxyimino-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid which melts at 230°C. after recrystallization from ethanol-water.

Sources & evidence

ORD record
ord-b406d0d0d8724e629e831a9e3103c9c7
Source dataset
uspto-grants-1976_08
Patent number
US03974212

Reaction notes

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