2,4-Dimethyl-3-pyridinecarboxylic acid → 1-(1,3,7-Trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)ethyl 2,4-dimethylpyridine-3-carboxylate

HRID 1283381Notes

Reaction equation

HRID 1283381 reaction equation
Cl[CH:2]([C:4]1[N:13]([CH3:14])[C:12]2[C:11](=[O:15])[N:9]([CH3:10])[C:8](=[O:16])[N:7]([CH3:17])[C:6]=2[N:5]=1)[CH3:3].[Na].[CH3:19][C:20]1[N:28]=[CH:27][CH:26]=[C:25]([CH3:29])[C:21]=1[C:22]([OH:24])=[O:23]>CN(C)C=O>[CH3:19][C:20]1[N:28]=[CH:27][CH:26]=[C:25]([CH3:29])[C:21]=1[C:22]([O:24][CH:2]([C:4]1[N:13]([CH3:14])[C:12]2[C:11](=[O:15])[N:9]([CH3:10])[C:8](=[O:16])[N:7]([CH3:17])[C:6]=2[N:5]=1)[CH3:3])=[O:23]

Participants

5

Reactant 3

HCID 15125612,4-Dimethyl-3-pyridinecarboxylic acidHCID 5360545SodiumHCID 681383658-alpha-Chloroethylcaffeine

Product 1

HCID 30436861-(1,3,7-Trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)ethyl 2,4-dimethylpyridine-3-carboxylate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.54 g of 8-α-chloroethylcaffeine are dissolved in 15 ml of anhydrous dimethylformamide, and 1.75 g of the sodium salt of dry 2,4-dimethylnicotinic acid are then added.

Sources & evidence

ORD record
ord-5bf6ce6e1954438f8fa1e0efbe6209ba
Source dataset
uspto-grants-1976_08
Patent number
US03975389

Reaction notes

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