Triethylamine → HCID 18668241, compound

HRID 128344Notes

Reaction equation

HRID 128344 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([NH:8][S:9]([CH2:12][CH3:13])(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.[C:21](Cl)(=[O:25])[C:22]([CH3:24])=[CH2:23]>C(Cl)Cl>[C:21]([O:1][C:2]1[CH:3]=[C:4]([NH:8][S:9]([CH2:12][CH3:13])(=[O:11])=[O:10])[CH:5]=[CH:6][CH:7]=1)(=[O:25])[C:22]([CH3:24])=[CH2:23]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 13528Methacryloyl chlorideHCID 836781HCID 836781, compound

Product 1

HCID 18668241HCID 18668241, compoundYield 82.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To 20.0 g (0.099 mol) of N-(3-hydroxyphenyl)ethanesulfonamide, 10.06 g (0.099 mol) of triethylamine and 150 ml of methylene chloride cooled to 0° C., was added a solution of 10.39 g (0.099 mol) of methacryloyl chloride in 100 ml of methylene chloride, dropwise. Stirring was continued at reduced temperature for 4 hours, after which the solution was washed once with 2 percent hydrochloric acid, twice with water and dried over magnesium sulfate. Concentration of the solution in vacuo gave 22.0 g (82.5 percent yield) of non-crystallizable oil.

Workup

  1. customfor 4 hours
  2. washafter which the solution was washed once with 2 percent hydrochloric acid, twice with water
  3. dry with materialdried over magnesium sulfate

Sources & evidence

ORD record
ord-daba65fd9945497b8de7d2999fd44da8
Source dataset
uspto-grants-1981_03
Patent number
US04259469

Reaction notes

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