Piperazine → HCID 54433626, compound

HRID 1283466Notes

Reaction equation

HRID 1283466 reaction equation
[CH2:1]([O:3][C:4]1[N:9]=[C:8](SC)[N:7]=[C:6]([N:12]2[CH2:17][CH2:16][S:15](=[O:18])[CH2:14][CH2:13]2)[C:5]=1[N+:19]([O-:21])=[O:20])[CH3:2].[NH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>CS(C)=O>[CH2:1]([O:3][C:4]1[N:9]=[C:8]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:7]=[C:6]([N:12]2[CH2:17][CH2:16][S:15](=[O:18])[CH2:14][CH2:13]2)[C:5]=1[N+:19]([O-:21])=[O:20])[CH3:2]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 54417899HCID 54417899, compound

Product 1

HCID 54433626HCID 54433626, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

50 gm (0.15 mol) of 6-ethoxy-2-methylthio-5-nitro-4-(1-oxido-thiomorpholino)-pyrimidine together with 64.8 gm (0.15 mol) of piperazine, were dissolved in 150 ml of dimethyl sulfoxide and the solution was stirred for 6 hours at room temperature. Then, the reaction mixture was poured into ice-water, the crystals formed thereby were suction-filtered off, and the filter cake was washed with water and recrystallized from ethanol. Yield: 39.3 gm (70.7% of theory); m.p. 222°-223°C.

Workup

  1. customthe crystals formed
  2. filtrationthereby were suction-filtered off
  3. washthe filter cake was washed with water
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-73ae17c120a04752aa226f365dc1f5f2
Source dataset
uspto-grants-1976_08
Patent number
US03975384

Reaction notes

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