N,N-Diethylethylenediamine → Tiapride

HRID 1283488Notes

Reaction equation

HRID 1283488 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:8][C:4]=1[C:5]([OH:7])=O.[CH2:16]([N:18]([CH2:22][CH3:23])[CH2:19][CH2:20][NH2:21])[CH3:17]>O1CCOCC1>[CH2:16]([N:18]([CH2:19][CH2:20][NH:21][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:10]=[CH:11][C:3]=1[O:2][CH3:1])[CH2:22][CH3:23])[CH3:17]

Participants

4

Reactant 2

HCID 60993N,N-DiethylethylenediamineHCID 1708405-Mesyl-o-anisic acid

Product 1

HCID 5467Tiapride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.3 g (0.01 mol) of 2-methoxy 5-methylsulfonylbenzoic acid, 2.9 g (0.025 mol) of N,N-diethyl ethylenediamine and 40 ml of dioxan are placed in a 100 ml balloon flask provided with a stirrer and a condenser.

Workup

  1. customprovided with a stirrer and a condenser

Sources & evidence

ORD record
ord-73c09dc60c3840659889add78b7c97db
Source dataset
uspto-grants-1976_08
Patent number
US03975434

Reaction notes

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