Potassium Cyanide → HCID 21409853, compound

HRID 1283556Notes

Reaction equation

HRID 1283556 reaction equation
[C-:1]#[N:2].[K+].Cl.[CH3:5][NH:6][CH3:7].[CH3:8][C:9](=O)[CH2:10][CH2:11][CH2:12][CH3:13]>O>[CH3:8][C:9]([N:6]([CH3:7])[CH3:5])([CH2:10][CH2:11][CH2:12][CH3:13])[C:1]#[N:2]

Participants

5

Reactant 3

HCID 9032Potassium CyanideHCID 10473Dimethylamine, hydrochlorideHCID 115832-Hexanone

Product 1

HCID 21409853HCID 21409853, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

A solution of potassium cyanide (34.20 g.,) in water (75 ml.) was added dropwise to a stirred solution of dimethylamine hydrochloride (40.8 g.,) and hexane-2-one (50 g., 0.5 mole) in water (60 ml.) cooled in an ice-water bath. The mixture was vigorously stirred for 24 hrs., diluted with water (200 ml.) and extracted with ether (4 × 200 ml.). The combined ether extracts were washed with water (4 × 200 ml.), dried (Na2SO4) and evaporated to leave a colourless oil which was distilled at 12 mm. to give a colourless oil which when distilled gave 2-methyl-2-dimethylamino-hexanenitrile as a colourless oil (51.547 g., 67%, b.p. 92°/12 mm).

Workup

  1. temperaturecooled in an ice-water bath
  2. extractionextracted with ether (4 × 200 ml.)
  3. washThe combined ether extracts were washed with water (4 × 200 ml.)
  4. dry with materialdried (Na2SO4)
  5. customevaporated
  6. customto leave a colourless oil which
  7. distillationwas distilled at 12 mm
  8. customto give a colourless oil which when
  9. distillationdistilled

Sources & evidence

ORD record
ord-99b3e8a930594b5ca8dcc5152381c313
Source dataset
uspto-grants-1976_08
Patent number
US03975443

Reaction notes

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