Hydrogen Peroxide → HCID 86733847, compound

HRID 1283592Notes

Reaction equation

HRID 1283592 reaction equation
[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([F:17])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[N:8]=2)[CH2:3][CH2:2]1.[OH:24]O>S(=O)(=O)(O)O>[O:24]=[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([F:17])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[N:8]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 21518487HCID 21518487, compound

Product 1

HCID 86733847HCID 86733847, compoundYield 31%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

1-(1-Oxido-thiomorpholino-3-piperazino-5-fluoro-isoquinoline was prepared analogous to Example 12 from 1-thiomorpholino-3-piperazino-5-fluoro-isoquinoline by oxidation with hydrogen peroxide in dilute sulfuric acid. M.p. 213°-215°C (from n-propanol/petroleum ether). Yield: 31% of theory.

Sources & evidence

ORD record
ord-bb53838be7a54b37979d8c6ae41e755e
Source dataset
uspto-grants-1976_08
Patent number
US03975524

Reaction notes

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