反应详情

0.200 G. of 2-(5-oxo-5 -H-dibenzo[a,d]cyclohepten-2-yl)propanal is dissolved in 10 ml. of methanol and 20 ml. of tetrahydrofuran, and 1 drop of 60% aqueous perchloric acid is added. The mixture is left for 1 hour then 2 drops of pyridine are added and the mixture added to water and ether. The organic layer is washed with water, dried and evaporated and the residue chromatographed on 5 gm. of silica gel, eluting with 50:50:1 hexane:ether:triethylamine to afford 1,1-dimethoxy 2-(5-oxo-5H-dibenzo[a,d]cyclohepten-2-yl)propane.

1. washThe organic layer is washed with water
2. customdried
3. customevaporated
4. customthe residue chromatographed on 5 gm
5. washof silica gel, eluting with 50:50:1 hexane