Hydrochloric Acid → 5-fluoro-1H-indazol-3-amine

HRID 1283711Notes

Reaction equation

HRID 1283711 reaction equation
[C:1]([C:3]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:4]=1[NH2:5])#[N:2].[N:11]([O-])=O.[Na+].Cl>>[NH2:2][C:1]1[C:3]2[C:4](=[CH:6][CH:7]=[C:8]([F:10])[CH:9]=2)[NH:5][N:11]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 27377042-Amino-5-fluorobenzonitrileHCID 23668193Sodium Nitrite

Product 1

HCID 43278965-fluoro-1H-indazol-3-amine

Procedure

By the procedure of Example 2, 13.6 g. of 2-cyano-4-fluoroaniline is treated with 8.0 g. of sodium nitrite and concentrated hydrochloric acid, followed by stannous chloride to give 3-amino-5-fluoroindazole.

Sources & evidence

ORD record
ord-ed1e662a57e14dce96aaf57815ac46d4
Source dataset
uspto-grants-1976_08
Patent number
USRE028939

Reaction notes

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