Trifluoroacetic acid → HCID 54325562, compound

HRID 1283852Notes

Reaction equation

HRID 1283852 reaction equation
[C:1]1([CH2:7][O:8][C:9](=[O:28])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH:16]2[CH:20]([C:21]([O:23]C(C)(C)C)=[O:22])[CH2:19][CH2:18][NH:17]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)[C:31]([OH:33])=[O:32]>>[C:1]1([CH2:7][O:8][C:9](=[O:28])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH:16]2[CH:20]([C:21]([OH:23])=[O:22])[CH2:19][CH2:18][N:17]2[C:31]([O:33][C:1]([CH3:7])([CH3:6])[CH3:2])=[O:32])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54268713HCID 54268713, compound

Product 1

HCID 54325562HCID 54325562, compound

Procedure

The product of Example 17 is dissolved in trifluoroacetic acid and the solution is stored at room temperature for one hour. The mixture is then concentrated to dryness in vacuo, and the residue is acylated with t-butyloxycarbonyl azide by the procedure described in Example 13 to obtain 3-carboxy-1-[(t-butyloxy)carbonyl]-2-pyrrolidineheptanoic acid phenylmethyl ester.

Workup

  1. concentrationThe mixture is then concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-972c3d0e568542539a7c58a900f6b4b9
Source dataset
uspto-grants-1976_08
Patent number
US03976660

Reaction notes

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