Hydrochloric Acid → ((2-Aminoethyl)thio)acetic acid, methyl ester, hydrochloride

HRID 1283959Notes

Reaction equation

HRID 1283959 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]([OH:8])=[O:7].[CH3:9]OC(OC)(C)C.[ClH:16]>CO>[ClH:16].[CH3:9][O:7][C:6]([CH2:5][S:4][CH2:3][CH2:2][NH2:1])=[O:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 64952,2-DimethoxypropaneHCID 4474780HCID 4474780, compound

Product 1

HCID 170337((2-Aminoethyl)thio)acetic acid, methyl ester, hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

13.5 g of S-(β-aminoethyl)mercaptoacetic acid and 10.8 g of 2,2-dimethoxy propane are added, successively, to a solution of 7.3 g of gaseous hydrochloride acid in 20 cc of methanol. The solution is permitted to stand for 12 hours at ambient temperature. The flakes formed (17.5 g) are filtered and washed with ethyl acetate. Fusion point = 100°C.

Workup

  1. customThe flakes formed (17.5 g)
  2. filtrationare filtered
  3. washwashed with ethyl acetate
  4. customFusion point = 100°C.

Sources & evidence

ORD record
ord-d67f649056674ccab262d2f495f48090
Source dataset
uspto-grants-1976_08
Patent number
US03976781

Reaction notes

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