反应详情

To a suspension of 5-ethoxy-1,3-dihydropyrrolo[4,3,2-de]isoquinoline (200 mg, 1 mmole), described in Example 5, in ethanol (2 ml), aqueous ammonium hydroxide (25%, 0.5 ml, 1.4 mmole) is added followed by 2.3 N HCl in ethanol (0.5 ml). The mixture is heated at reflux for 0.5 hour, then ether is added and the light green crystalline precipitate collected to give the hydrochloride salt of the title compound, 5-amino-1,3-dihydropyrrol[4,3,2-de]isoquinoline hydrochloride, mp 227° - 228°C.

1. temperatureThe mixture is heated
2. temperatureat reflux for 0.5 hour
3. customthe light green crystalline precipitate collected