Hydrochloric Acid → HCID 135755441, compound

HRID 1284066Notes

Reaction equation

HRID 1284066 reaction equation
[CH3:1][N:2]1[C:6]([S:7][CH2:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:27]CC4C=CC=CC=4)=[C:16]([O:19]CC4C=CC=CC=4)[CH:17]=3)[CH2:12][CH2:11][N:10]=2)=[N:5][N:4]=[N:3]1.[ClH:35]>C(O)C>[ClH:35].[CH3:1][N:2]1[C:6]([S:7][CH2:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([OH:27])=[C:16]([OH:19])[CH:17]=3)[CH2:12][CH2:11][N:10]=2)=[N:5][N:4]=[N:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12773939HCID 12773939, compound

Product 1

HCID 135755441HCID 135755441, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-(1-methyl-1H-tetrazol-5-yl)thiomethyl- 6,7-dibenzyloxy-3,4-dihydroisoquinoline (1g), 99% ethanol (10 ml) and concentrated hydrochloric acid (10 ml) was refluxed for 3 hours. After the reaction the solvent was distilled off and the residue was crystallized from a mixture of isopropanol and ether to give 1-(1-methyl-1H-tetrazol-5-yl)thiomethyl- 6,7-dihydroxy-3,4-dihydroisoquinoline hydrochloride (0.75 g), mp 130°C (dec.).

Workup

  1. temperaturewas refluxed for 3 hours
  2. customAfter the reaction the solvent
  3. distillationwas distilled off
  4. customthe residue was crystallized from a mixture of isopropanol and ether

Sources & evidence

ORD record
ord-25cf3e53e53742dfaafa327cb5a6e533
Source dataset
uspto-grants-1976_08
Patent number
US03978063

Reaction notes

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