反应详情

A mixture of 25.5 g of ethyl 2-[4-(chloroacetyl)phenyl]propionate, 50 ml of ethanol and 19 g of 2-aminopyrimidine is heated under reflux for 3 hours. The ethanol is distilled off under reduced pressure, and water is added to the residue. The mixture is extracted with ethyl acetate, and the extract is washed with water, dried and concentrated to give a reddish brown oil. To the oil are added ethyl acetate and isopropyl ether, and the crystalline precipitate is filtered off and recrystallized from ethanol to give 8.4 g of ethyl 2-[4-(imidazo[1,2-a]pyrimidin-2-yl)phenyl]propionate as colorless scales melting at 171°-173°C.

1. temperatureis heated
2. temperatureunder reflux for 3 hours
3. distillationThe ethanol is distilled off under reduced pressure, and water
4. additionis added to the residue
5. extractionThe mixture is extracted with ethyl acetate
6. washthe extract is washed with water
7. customdried
8. concentrationconcentrated
9. customto give a reddish brown oil
10. filtrationthe crystalline precipitate is filtered off
11. customrecrystallized from ethanol