Ethyl formate → HCID 21515920, compound

HRID 1284269Notes

Reaction equation

HRID 1284269 reaction equation
[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH2:16])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH:21](OCC)=[O:22]>>[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH:16][CH:21]=[O:22])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 203722482-(alpha,alpha,beta,beta-Tetrafluorophenethyl)benzylamine

Product 1

HCID 21515920HCID 21515920, compound

Procedure

2-(α,α,β,β-Tetrafluorophenethyl)benzylamine, 1.4 g. (0.005 mole), in 100 ml. of ethyl formate, is stirred and heated to refluxing for about 20 hours. Evaporation of the solution to dryness and trituration of the residual solid with petroleum ether gives N-[2-(α,α,β,β-tetrafluorophenethyl)benzyl]formamide, m.p. 61°-75°C.

Workup

  1. temperatureheated
  2. temperatureto refluxing for about 20 hours
  3. customEvaporation of the solution to dryness and trituration of the residual solid with petroleum ether

Sources & evidence

ORD record
ord-45fe016111984fd9a917312ebb0d4386
Source dataset
uspto-grants-1976_08
Patent number
US03978127

Reaction notes

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