Tetrahydrofuran → Dimethyl 2-oxo-3-phenoxypropylphosphonate

40.1 g. of dimethyl methylphosphonate were dissolved in 200 ml. of anhydrous tetrahydrofuran, to which 154 ml. of a 2N n-butyllithium solution in n-hexane were added dropwise whilst maintaining the temperature from -60°C. to -70°C. After stirring for 20 minutes, 15 g. of ethyl phenoxyacetate in 80 ml. of tetrahydrofuran were added to the solution. The mixture was stirred at the same temperature for 2 hours and then at room temperature overnight. The reaction mixture was neutralized with acetic acid and concentrated under reduced pressure. The residue was dissolved in a small amount of water and extracted with diethyl ether. The ethereal extracts were washed with an aqueous sodium chloride solution, dried over magnesium sulphate and concentrated under reduced pressure. The residue was purified by distillation in vacuo to give 18.9 g. of the title compound having the following characteristics:

1. temperaturewhilst maintaining the temperature from -60°C. to -70°C
2. stirringThe mixture was stirred at the same temperature for 2 hours
3. customat room temperature
4. customovernight
5. concentrationconcentrated under reduced pressure
6. dissolutionThe residue was dissolved in a small amount of water
7. extractionextracted with diethyl ether
8. washThe ethereal extracts were washed with an aqueous sodium chloride solution
9. dry with materialdried over magnesium sulphate
10. concentrationconcentrated under reduced pressure
11. distillationThe residue was purified by distillation in vacuo
12. customto give 18.9 g

ORD record

ord-fe8ba4c67120464da4dc1f5e8fe35de7

Source dataset

uspto-grants-1976_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US03978229