Methyl Isocyanate → HCID 13423320, compound

HRID 1284469Notes

Reaction equation

HRID 1284469 reaction equation
[C:1]1(/[C:7](/[C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[CH:8]\[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][OH:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:21][N:22]=[C:23]=[O:24]>C(N(CC)CC)C>[CH3:21][NH:22][C:23]([O:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]/[CH:8]=[C:7](\[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)/[C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)=[O:24]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 13417327HCID 13417327, compound

Product 1

HCID 13423320HCID 13423320, compoundYield 91.6%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

(E)-7-Phenyl-7-(3-pyridyl)-6-hepten-1-ol (2.0 g, 7.4 mmoles) was reacted with methyl isocyanate (500 mg, 8.8 mmoles) in the presence of triethylamine in the same manner as Example 9 to give 1-methylaminocarbonyloxy-(E)-7-phenyl-7-(3-pyridyl)-6-heptene (2.2 g) (Compound Id-24) as an oil. This compound forms a crystalline salt of oxalic acid.

Sources & evidence

ORD record
ord-09199850fa4e4dcf9f4355691ae2ec8a
Source dataset
uspto-grants-1986_01
Patent number
US04563446

Reaction notes

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